hyaluronic acid

SYMATESE works with BDDE cross linked Hyaluronic acid for the design of innovative hyaluronic acid fillers and other medical devices. Cross linked hyaluronic acid is a derivative from a naturally occurring macromolecule belonging to the glycosaminoglycan family.

Hyaluronic acid is composed of repeating disaccharide units of glucuronic acid and N-acetylglucosamine. After transformation into crosslinked hyaluronic acid, it exhibits unique properties allowing for many different applications in the medical field:
Hyaluronic acid is a natural component of most human and animal tissues with an identical primary chemical structure whatever the extraction source. It has a rapid and well-known metabolism.
This macromolecule is use in medical field for very long time and is recognised as safe for implantable medical device.
Cross linked hyaluronic acid keeps a strong hydrophilic nature and its structure occupies a very large volume in physiological conditions.
Cross linked hyaluronic acid exhibits viscoelastic properties of great interest in medical context.

Still in many of those applications, the medical device’s performance and quality does not only rely on the hyaluronic molecule itself but rather on the quality of the cross linked hyaluronic acid transformation technology. For example,hyaluronic acid fillers need to be properly crosslinked, purified and formulated to be safe and match aesthetic or in visco-supplementation use. In most cases, the added value of the device is directly linked to its transformation technology by crosslinking.
For the last 15 years, SYMATESE has developed a wide array of hyaluronic acid fillers transformation technologies to match the needs of a wide array of therapeutic domains


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