hyaluronic acid

Cross linked hyaluronic acid is the main component of key medical devices in many medical fields:


Hyaluronic acid fillers for wrinkles and mesotherapy Skin aging results in wrinkles formation and volume loss. Cross linked hyaluronic acid is the gold standard used since 20 years to treat wrinkles and depression of the face. SYMATESE hyaluronic acid fillers are indicated for facial rejuvenation, in a wide array of indications such as wrinkles treatment, mid face volume restauration, lips volume correction…


Viscous solution for cataract surgery, vitreous substitute or new innovative use in ophthalmology
Hyaluronic acid solution has been used for a long-time during cataract surgery. Now, the interest of crosslinked Hyaluronic acid is investigated in ophthalmology for many other indications, from glaucoma treatment to eye surface lubrication.

Rheumatology: Viscosupplementation

The use of injectable Hyaluronic solution to treat joint pain dates back from the 90’s. It allows treating symptom of arthritis. Initially, product were linear, but more recently new products based on crosslinked hyaluronic acid have been added in the therapeutic tool for joint treatment. The use of crosslinked hyaluronic acid gel allows for a single injection treatment instead of the 3 to 5 injections in case of non-crosslinked Hyaluronic acid solution.

Surgery: Anti-adhesion barrier, Wound healing, wound dressing

Hyaluronic acid is widely used in both wound healing and surgical situation. Its unique properties are very interesting for the treatment of wounds. After surgery, it is used to prevent adhesion, either in film or in gel form.
The very good biocompatibility and absorbability of hyaluronic acid are of great interest in that case

Urology: Soft tissue filler for treatment of vesico-urethral reflux

As for aesthetic use, the gel properties of crosslinked hyaluronic acid are very interesting as volumizer of other soft tissue. It can be used inurology to correct sphincter malfunction by injection. Low resorption rate of the gel allows for its lasting effect.
The volumizing properties of the gel are also investigated in other therapeutics area such as prostate radiotherapy. The gel is used as an injectable spacer to reduce side effect of irradiation on nearby tissue during prostate cancer treatment.

For all those therapeutic areas, the key point is the Hyaluronic acid transformation by crosslinking.
One of its most successful achievements of SYMATESE is the development of a versatile cross-linked hyaluronic acid technologies. Those technologies allows transforming hyaluronic acid solution into unique tailor-made gels with multiple potential uses, like hyaluronic acid fillers. One of those technology has been successfully tested and marketed in aesthetic dermatology, through a partnership with a world class leader. This has positioned the company as a leader among dermal fillers manufacturers. Product from those technology have also been tested in clinical trial in other indications such as visco-supplementation, ophthalmology or radiotherapy.
The cross linked hyaluronic acids are produced in a new and dedicated production line meeting international quality and regulatory requirements, placing SYMATESE as a leading manufacturer for crosslinked hyaluronic acid gel.

Our BDDE cross linking hyaluronic acid technologies, along with the dedicated production line, make SYMATESE, an ideal partner for companies searching for a fully integrated solution, from the design to production of new hyaluronic acid fillers or crosslinked hyaluronic acid gel. Based on the analysis of their partner’s needs, SYMATESE can design a project going from the needs to the commercialisation of the device.


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