Collagen represents 30% of the proteins in your body. It is in your bones, muscles, and blood, and it constitutes 75% of your skin. It is responsible for skin elasticity and is the perfect matrix for healthy joints, tendons, ligaments, etc.
Collagen is the most abundant protein in mammal tissue. Bovine Collagen type I has been used for centuries in medical applications. It is a key raw material for numerous medical devices and can be found for instance as surgical haemostatics, in Bone Void Fillers, and in dermal regeneration matrices. It can be sourced from various animal species and tissues.
Collagen Domains of Application
SYMATESE has already purified collagen bulk raw materials, semi-finished or collagen medical devices for usage in the following areas:

VASCULAR SURGERY
SYMATESE supplies medical device coating for example in vascular prosthesis. Using bovine Collagen type I, these collagen solutions allow vascular prostheses optimisation by improving anti-thrombogenicity, biocompatibility and tightness properties.

VISCERAL SURGERY
SYMATESE supplies medical device coating solution dedicated to improve parietal prostheses and anti-adhesion films properties. SYMATESE products are designed to manage interfacial performance of supporting devices to prevent adhesion formation while providing biocompatibility.

ORTHOPAEDIC SURGERY
SYMATESE offers collagen medical devices dedicated to orthopaedic surgery, more precisely for hard tissue scaffolding. SYMATESE proposes bone substitutes made of bovine Collagen type I and matrices for cartilage engineering exhibiting osteoconductive effect for bone or cartilaginous defects repair and regeneration.

DERMAL RECONSTRUCTION
SYMATESE also focuses on burns management and dermal reconstruction by proposing a bi-layered dermal regeneration matrix which is used to provide a suitable Healing environment to skin defects.

DENTAL SURGERY
SYMATESE is present in dental surgery by way of two classes of products:
- SYMATESE supplies bone substitutes based on a combination of bovine collagen type I and hydroxyapatite which provide an osteoconductive effect. These bone substitutes are used in maxillo-facial surgery and odonto-stomatology;
- SYMATESE also supplies haemostatic sponges to allow practitioners to achieve haemostasis following dental extraction for example.

HAEMOSTASIS
SYMATESE supplies haemostatic sponges for general surgery intended to be used by surgeons to control bleeding on surgical site. SYMATESE is also involved in bleeding control following haemodialysis by proposing a compressive haemostatic sponge to overcome post-dialysis complications.

Bovine Collagen Type I, the most widely used collagen, can be found in various forms and with different characteristics, from insoluble native collagen fibres to soluble collagen solutions. Each collagen raw material form possesses different properties that allow for the design of tailor-made collagen medical devices according to specific need, such as:
- insoluble native collagen fibres for applications such as surgical hemostasis and wound Healing,
- soluble collagen solutions for anti-adhesion film,
- coating of medical devices, and more.
SYMATESE has extracted and transformed bovine collagen Type I for more than 30 years in compliance with sanitary and regulatory requirements requested for medical applications (purity, traceability, certificates).
SYMATESE delivers a premium bovine Collagen type I used in many collagen based medical devices Medical devices. Manufacturing by SYMATESE are is in compliance with the standard NF EN ISO 22442 parts 1 to 3 (2016).
SYMATESE also extracts collagen from different tissues (hides, tendons, kidney or kneecap) and from different animal species (bovine, porcine, equine or fish). For products of bovine origin, SYMATESE has validated two sourcing : from US and from Australia.
SYMATESE bovine collagen raw material is also in compliance with the European requirements:
Regulation (UE) N° 722/2012 of 8 August 2012
concerning particular demands with regards to the requirements laid down in Council Directives 90/385/EEC and 93/42/EEC with respect to active implantable medical devices and medical devices manufactured utilising tissues of animal origin,
Monograph N° 1483 of European Pharmacopieia
“Products with risk of transmitting agents of animal spongiform encephalopathies”. SYMATESE has obtained a certificate of suitability for its 2 bovine collagen Type I raw materials.
The risk management process implemented by SYMATESE guarantees complete microbiological safety to the users.
Off-the-Shelf Collagen Solutions

Collagen raw material available for medical application
SYMATESE control internally the complete extraction and purification process of its collagen raw material from the tissue to the final product. Its different production and purification technologies allow for a unique variety of collagen forms with different properties and specifications.
Type I Collagen Bovine Origin
PRODUCTS | CHARACTERISTICS | REFERENCE | QUANTITY |
---|---|---|---|
Acido soluble collagen solution | Sterile bovine collagen Type I solution at 5 mg/ml approx in acetic acid 0.017 N, from calf hides, for coating of medical devices Storage : 2-8°C |
ACI020 ACI100 ACI600 |
20 ml 100 ml 6 x 100 ml |
Bovine collagen Type I | Dry, from calf hides Solubility : partially soluble in acid Storage : at room temperature |
FIBUS010 FIBUS025 FIBUS050 FIBUS100 FIBUS500 |
100 mg 250 mg 500 mg 1 g 5 g |
Purified bovine collagen Type I | Dry, from calf hides Pepsin extraction Solubility : acid soluble Storage : – 20°C |
CBPE2US010 CBPE2US025 CBPE2US050 CBPE2US100 CBPE2US500 |
100 mg 250 mg 500 mg 1 g 5 g |
Thank you for contacting us to establish a quotation according to your desired volumes by clicking and filling the following template:
Collagen Raw Material Customized to your Needs
With a unique experience and know-how of collagen transformation, SYMATESE is the ideal partner for a company that needs collagen medical devices or collagen raw material, including collagen matrices, medical device coating collagen solutions, collagen sponges, and more.
As functional requirements for each product are specific, we tailor the collagen raw material specifications to the exact needs of our customers.

Transformation Technologies

SYMATESE collagen raw material can be used as starting material for a collagen medical device, and then, SYMATESE masters a wide range of collagen transformation technologies:
- Enzymatic processes
- Crosslinking (Through various chemical or auto-crosslinking technologies)
- Freeze drying
- Film casting
- Chemical transformation, grafting
- Co formulation with other biopolymer or other compounds.
Raw Material Properties
Formulation with purified soluble collagen could also be used to obtain filterable heated collagen solution that will display gelatin-like properties with a full chain structural integrity and a unique level of purity. This heated collagen will exhibit unique mechanical properties along with:
- Full traceability
- Complete endotoxin level control
- Controlled contamination level or sterile solution