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Collagen is the most abundant protein in mammal tissue.

It has been used for centuries in medical applications. It is a key raw material for numerous medical devices and can for example be found in: Surgical haemostatics, Bone Graft Substitutes, …

It can be sourced from different animal species, and tissues.

Typ I Collagen, the most widely used type of collagen can be found in different forms with different quality levels, from insoluble native collagen fibers to soluble forms. Each form can exhibit specific properties that can be transformed into a tailor made solution for a specific need:

  • Insoluble native collagen fiber for surgical hemostasis and wound Healing,
  • Soluble collagen for anti-adhesion, coating of medical devices…

SYMATESE has extracted and transformed collagen for more than 30 years in compliance with sanitary and regulatory requirements requested for medical applications (traceability, certificates).

SYMATESE extracts collagen from different tissues (hides, tendons, kidney, kneecap) and from different animal species (bovine, porcine). For products of bovine origin, SYMATESE has validated an American and Australian source for animal tissue, and for porcine products a French source. Medical devices manufactured by SYMATESE from animal tissue are in compliance with the standard NF EN ISO 22442 parts 1 to 3 (2008).

SYMATESE’s collagen is in compliance with the European requirements:

  • Regulation (UE) N° 722/2012 of 8 August 2012 concerning particular demands with regards to the requirements laid down in Council Directives 90/385/EEC and 93/42/EEC with respect to active implantable medical devices and medical devices manufactured utilising tissues of animal origin.
  • Monograph N° 1483 of European Pharmacopieia : "Products with risk of transmitting agents of animal spongiform encephalopathies". SYMATESE has obtained a certificate of suitability for its 2 Type I bovine collagen raw materials.

The risk management process put in place by SYMATESE guarantees complete microbiological safety to the users.

COLLAGENS AVAILABLE FOR MEDICAL APPLICATIONS

SYMATESE masters internally the complete extraction and purification process of its collagen from the collection tissue to the final product.

Its different production and purification technologies allow for a unique variety of collagen forms with different properties.

TYPE I COLLAGEN BOVINE ORIGIN

PRODUCTS CHARACTERISTICS REFERENCE QUANTITY
Acido soluble collagen solution Sterile collagen solution at 5 mg/ml approx in acetic acid 0.017 N, from calf hides, for coating of medical devices
Storage : 2-8°C
ACI020
ACI100
ACI600
20 ml
100 ml
6 x 100 ml
Type I collagen Dry, from calf hides
Solubility : partially soluble in acid
Storage : at room temperature
FIBUS010
FIBUS025
FIBUS050
FIBUS100
FIBUS500
100 mg
250 mg
500 mg
1 g
5 g
Purified Type I collagen Dry, from calf hides
Pepsin extraction
Solubility : acid soluble
Storage : - 20°C
CBPE2US010
CBPE2US025
CBPE2US050
CBPE2US100
CBPE2US500
100 mg
250 mg
500 mg
1 g
5 g

TYPE I COLLAGEN PORCINE ORIGIN

PRODUCTS CHARACTERISTICS REFERENCE QUANTITY
Type I collagen Dry, from porcine hides
Solubility : partially soluble in acid
Storage : at room temperature
FIBP010
FIBP025
FIBP050
FIBP100
FIBP500
100 mg
250 mg
500 mg
1 g
5 g

TYPE II COLLAGEN PORCINE ORIGIN

PRODUCTS CHARACTERISTICS REFERENCE QUANTITY
Purified Type II collagen Dry, from porcine articular cartilage
Pepsin extraction
Solubility : acid soluble
GAG content < 0.1 %
Type I collagen free
Storage : - 20°C
CII025
CII100
CII1000
25 mg
100 mg
1 g

TYPE IV COLLAGEN PORCINE ORIGIN

PRODUCTS CHARACTERISTICS REFERENCE QUANTITY
Purified Type IV collagen Dry, from porcine kidney
Pepsin extraction
Solubility : acid soluble
Storage : - 20°C
CIV025
CIV100
25 mg
100 mg

Thank you for contacting us to establish a quotation according to your desired volumes by clicking on the following link: contact@symatese.com

CUSTOMIZED COLLAGEN FOR YOUR NEED

Its unique experience and know-how of collagen transformation make SYMATESE the ideal company for a partner in need of medical grade collagen material or of a collagen based medical device.

As in many cases, if the functional requirements of the product are specific, SYMATESE will propose to tailor collagen specifications to the exact need of its customer.

SYMATESE collagen can be used as starting material for medical devices. SYMATESE masters a wide range of collagen transformation technologies:

  • Crosslinking (through various chemical or auto-crosslinking technologies)
  • Freeze drying,
  • Film casting,
  • Chemical transformation, grafting,
  • Co formulation with other biopolymer.

Formulation with active heated collagen: purified soluble collagen could also be used to obtain a heated collagen solution that will display gelatin-like properties with a full structural integrity and a unique level of purity. This heated collagen will exhibit unique mechanical properties along with :

  • Full traceability,
  • Complete endotoxin level control,
  • Controlled contamination level or sterile solution.